Clinical Toxicology (Toxicodynamics and Toxicokinetics) Quiz

I. IDENTIFICATION:

1. & 2 ____________________________Identify the two roles of the target molecule.
2. _______________________________
3. _______________________________It is called tissue involution or internal elimination of dead cells.
4. ______________________________ This particular drug of abuse increases release and diminish uptake of norepinephrine, serotonin and dopamine.
5. ______________________________ Transcribe DDT.
6. ______________________________ The term used to denote the cell or tissue that the drug has to act on.
7. ______________________________ Transcribe GABA.
8. ______________________________ This decreases hydrolysis of acetylcholine.
9. & 10______________________________ These type of drugs produce inhibitory
effect on the muscarinic receptors (M2 and M3). __________________________
11. ______________________________ They act on voltage-gated Na+ channels.
12. _______________________________Transcribe NMDA.
13. _______________________________Transcribe ATP
14. _______________________________ Transcribe ADP
15. _______________________________ Transcribe ECT.

CHOICES FOR 16- 25

A. DYSREGULATION OF GENE EXPRESSION
B. DYSREGULATION OF ONGOING CELLULAR FUNCTION
C. CELLULAR MAINTENANCE DYSFUNCTION
D. EXTERNAL MAINTENANCE DYSFUNCTION

16. Inappropriate cell function
17. Impaired ATP synthesis
18. Impaired Calcium regulation
19. Inappropriate protein synthesis
20. Impaired function of integrated systems
21. Impaired microtubular function
22. Inappropriate muscular activity
23. Inappropriate neuromuscular activity
24. Cell injury and death
25. Impaired membrane function

TRUE OR FALSE: IN THE FIRST BLANK, WRITE WHETHER TRUE OR FALSE, IF FALSE UNDERLINETHE WORD/S THAT MAKE/S IT FALSE AND WRITE THE CORRECT WORD IN THE SECOND BLANK.

1. _______ ________ Toxicodynamics involve toxicities interfering with cells specialized to provide support to other cells, tissues or whole organism.
2. _______ ________Repair involves only the internal cellular structure.
3. _______ ________ Alcohol converted to toxic metabolite produces direct injury .
4. _______ ________Alcohol stimulates GABA receptor and inhibits NMDA receptor
5. _______ ________Chronic intake of ethanol causes necrosis, cirrhosis, cancer of the lungs.
6. _______ ________Arsenic and mercury cause disrepair of the cells.

ESSAY: DISCUSS CONCISELY THE FOLLOWING.

1. DISCUSS THE POTENTIAL STAGES IN THE DEVELOPMENT OF TOXICITY.( 10 PTS.)

2. WHAT IS THE SIGNIFICANCE OF TOXICODYNAMICS? ( 10 PTS.)